Objective:To observe the resuhs of intraperitoneal perfusion chemotherapy combined with microwave hyperthermia for advanced gastrointestinal malignances, nethods:A total of 60 patients with advanced gastrointestinal malignances were divided randomly into two groups:peritoneal chemotherapy plus microwave regional hyperthermia ( Group A, 30 patients) and peritoneal chemotherapy alone ( Group B, 30 cases). Results: CR + PR rates for gastric cancer, colorectal cancer and both in Group A were 58.8% , 69.2% and 63.3% , respectively;In Group B were 40.0% ,33.3% and 36.7% ( P<0.05 ). Conclusion: Thermo - chemotherapy group compared with peritoneal chemotherapy alone is effective to alleviate the condition, improve the quality of life of patients with advanced cancer, it is worthy of clinical application.