Objective To clarify the method, advantage and curative effect of intraperitoneal perfusion cooperate with thermotherapy for ovarian cancer, gastric cancer and colon cancer. Methods Using this methods to treat with 48 cases of ovarian cancer, gastric cancer, colon cancer and following up for three years, we got the clinical analysis and curative appraise by referring to some literature. Result There was very well effect on 26 cases, some effect on 15 cases, very little effect on 7 cases, we did not fred any syndrome such as haemorrhage, intestines conglutination putrescence in these cases. Conclusions This method enhanced curative effect of medicament, reduced side-effect of chronchemotherapy, curative effect very well.